The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

The cellular entry of severe acute respiratory syndrome-associated coronaviruses types 1 and 2 (SARS-CoV-1 and -2) requires sequential protease processing of the viral spike glycoprotein. The presence of a polybasic cleavage site in SARS-CoV-2 spike at the S1/S2 boundary has been suggested to be a f...

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Detalles Bibliográficos
Autores principales: Winstone, Helena, Lista, Maria Jose, Reid, Alisha C., Bouton, Clement, Pickering, Suzanne, Galao, Rui Pedro, Kerridge, Claire, Doores, Katie J., Swanson, Chad M., Neil, Stuart J. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Cellular Response to Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104117/
https://www.ncbi.nlm.nih.gov/pubmed/33563656
http://dx.doi.org/10.1128/JVI.02422-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104117/
https://www.ncbi.nlm.nih.gov/pubmed/33563656
http://dx.doi.org/10.1128/JVI.02422-20

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