E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation

Intestinal fungi are critical for modulating host immune homeostasis and underlying mechanisms remain unclear. We show that dendritic cell (DC)–specific deficiency of casitas B-lineage lymphoma (c-Cbl) renders mice susceptible to dextran sodium sulfate (DSS)–induced colitis. Mechanistically, we iden...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Jie-Lin, He, Hui-Qian, Yu, Yao, Liu, Tao, Ma, Shu-Jun, Li, Fan, Jiang, Yan-Shan, Lin, Xin, Li, De-Dong, Lv, Quan-Zhen, Ma, Hui-Hui, Jia, Xin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104877/
https://www.ncbi.nlm.nih.gov/pubmed/33962939
http://dx.doi.org/10.1126/sciadv.abe5171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104877/
https://www.ncbi.nlm.nih.gov/pubmed/33962939
http://dx.doi.org/10.1126/sciadv.abe5171

Ejemplares similares