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E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation

Intestinal fungi are critical for modulating host immune homeostasis and underlying mechanisms remain unclear. We show that dendritic cell (DC)–specific deficiency of casitas B-lineage lymphoma (c-Cbl) renders mice susceptible to dextran sodium sulfate (DSS)–induced colitis. Mechanistically, we iden...

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Detalles Bibliográficos
Autores principales:	Duan, Jie-Lin, He, Hui-Qian, Yu, Yao, Liu, Tao, Ma, Shu-Jun, Li, Fan, Jiang, Yan-Shan, Lin, Xin, Li, De-Dong, Lv, Quan-Zhen, Ma, Hui-Hui, Jia, Xin-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104877/ https://www.ncbi.nlm.nih.gov/pubmed/33962939 http://dx.doi.org/10.1126/sciadv.abe5171

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