Structural insights into integrin α(5)β(1) opening by fibronectin ligand

Integrin α(5)β(1) is a major fibronectin receptor critical for cell migration. Upon complex formation, fibronectin and α(5)β(1) undergo conformational changes. While this is key for cell-tissue connections, its mechanism is unknown. Here, we report cryo–electron microscopy structures of native human...

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Detalles Bibliográficos
Autores principales: Schumacher, Stephanie, Dedden, Dirk, Nunez, Roberto Vazquez, Matoba, Kyoko, Takagi, Junichi, Biertümpfel, Christian, Mizuno, Naoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104898/
https://www.ncbi.nlm.nih.gov/pubmed/33962943
http://dx.doi.org/10.1126/sciadv.abe9716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104898/
https://www.ncbi.nlm.nih.gov/pubmed/33962943
http://dx.doi.org/10.1126/sciadv.abe9716

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