SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate replication and evasion of the host immune response. Here, we report that co-culture of human cells ex...

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Detalles Bibliográficos
Autores principales: Sanders, David W, Jumper, Chanelle C, Ackerman, Paul J, Bracha, Dan, Donlic, Anita, Kim, Hahn, Kenney, Devin, Castello-Serrano, Ivan, Suzuki, Saori, Tamura, Tomokazu, Tavares, Alexander H, Saeed, Mohsan, Holehouse, Alex S, Ploss, Alexander, Levental, Ilya, Douam, Florian, Padera, Robert F, Levy, Bruce D, Brangwynne, Clifford P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104966/
https://www.ncbi.nlm.nih.gov/pubmed/33890572
http://dx.doi.org/10.7554/eLife.65962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104966/
https://www.ncbi.nlm.nih.gov/pubmed/33890572
http://dx.doi.org/10.7554/eLife.65962

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