Low rotational barriers for the most dynamically active methyl groups in the proposed antiviral drugs for treatment of SARS-CoV-2, apilimod and tetrandrine

A recent screening study highlighted a molecular compound, apilimod, for its efficacy against the SARS-CoV-2 virus, while another compound, tetrandrine, demonstrated a remarkable synergy with the benchmark antiviral drug, remdesivir. Here, we find that because of significantly reduced potential ener...

Descripción completa

Detalles Bibliográficos
Autores principales: Mamontov, Eugene, Cheng, Yongqiang, Daemen, Luke L., Kolesnikov, Alexander I., Ramirez-Cuesta, Anibal J., Ryder, Matthew R., Stone, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105138/
https://www.ncbi.nlm.nih.gov/pubmed/33994552
http://dx.doi.org/10.1016/j.cplett.2021.138727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105138/
https://www.ncbi.nlm.nih.gov/pubmed/33994552
http://dx.doi.org/10.1016/j.cplett.2021.138727

Ejemplares similares