Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase

Our understanding of enzymes with high substrate ambiguity remains limited because their large active sites allow substrate docking freedom to an extent that seems incompatible with stereospecificity. One possibility is that some of these enzymes evolved a set of evolutionarily fitted sequence posit...

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Detalles Bibliográficos
Autores principales: Cea-Rama, Isabel, Coscolín, Cristina, Katsonis, Panagiotis, Bargiela, Rafael, Golyshin, Peter N., Lichtarge, Olivier, Ferrer, Manuel, Sanz-Aparicio, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105184/
https://www.ncbi.nlm.nih.gov/pubmed/33995922
http://dx.doi.org/10.1016/j.csbj.2021.04.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105184/
https://www.ncbi.nlm.nih.gov/pubmed/33995922
http://dx.doi.org/10.1016/j.csbj.2021.04.041

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