Cargando…

Migration and invasion of NSCLC suppressed by the downregulation of Src/focal adhesion kinase using single, double and tetra domain anti- CEACAM6 antibodies

Carcinoembryonic antigen-related cell adhesion molecules 6 (CEACAM6) is a cell adhesion receptor. Expression of CEACAM6 in non-small cell lung cancer (NSCLC) associated with tumor progression and metastatic condition via Src/FAK signaling pathway. We established three anti-CEACAM6 antibodies with va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Shang-Jung, Arundhathi, Arivajiagane, Wang, Hsiang-Ching, Chen, Chiao-Yun, Cheng, Tsai-Mu, Yuan, Shyng-Shiou F., Wang, Yun-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105299/ https://www.ncbi.nlm.nih.gov/pubmed/33934053 http://dx.doi.org/10.1016/j.tranon.2021.101057

Ejemplares similares

Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src
por: Müller, Mario M., et al.
Publicado: (2009)

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
por: Wu, Jui-Chung, et al.
Publicado: (2015)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion
por: Durand, Nisha, et al.
Publicado: (2017)

Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments
por: Guo, Xiaohua, et al.
Publicado: (2020)

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy
por: Sandilands, Emma, et al.
Publicado: (2015)

Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation
por: Mima, Junko, et al.
Publicado: (2013)

Overexpression of CEACAM6 activates Src-FAK signaling and inhibits anoikis, through homophilic interactions in lung adenocarcinomas
por: Kim, Eun Young, et al.
Publicado: (2022)

Studying Cellular Focal Adhesion Parameters with Imaging and MATLAB Analysis
por: Yu, Ling-Yea, et al.
Publicado: (2023)

Erratum to: Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
por: Chen, Chang-Chiang, et al.
Publicado: (2017)

Effects of Electrical Stimulation on the Signal Transduction-Related Proteins, c-Src and Focal Adhesion Kinase, in Fibroblasts
por: Katoh, Kazuo
Publicado: (2022)

CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner
por: Matsuda, Jun, et al.
Publicado: (2022)

Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
por: Blumenthal, Rosalyn D, et al.
Publicado: (2007)

Role of CEACAM1 and CEACAM20 in an In Vitro Model of Prostate Morphogenesis
por: Zhang, Hui, et al.
Publicado: (2013)

c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly
por: Schimmel, Lilian, et al.
Publicado: (2020)

Cell Invasion by Neisseria meningitidis Requires a Functional Interplay between the Focal Adhesion Kinase, Src and Cortactin
por: Slanina, Heiko, et al.
Publicado: (2012)

Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation
por: Ross, Sarah H., et al.
Publicado: (2012)

Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration
por: Zhang, Yijun, et al.
Publicado: (2016)

Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase
por: Fatherree, Jackson P., et al.
Publicado: (2022)

CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2
por: Vadhan, Anupama, et al.
Publicado: (2022)

A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src
por: Wang, Yu, et al.
Publicado: (2011)

Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms
por: Gaur, Shikha, et al.
Publicado: (2008)

Focal overexpression of CEACAM6 contributes to enhanced tumourigenesis in head and neck cancer via suppression of apoptosis
por: Cameron, Sarina, et al.
Publicado: (2012)

CEACAM6 promotes cholangiocarcinoma migration and invasion by inducing epithelial-mesenchymal transition through inhibition of the SRC/PI3K/AKT signaling pathway
por: Liu, Chen, et al.
Publicado: (2022)

Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
por: Tsai, Min-Shao, et al.
Publicado: (2018)

Repulsive Guidance Molecule a Inhibits Angiogenesis by Downregulating VEGF and Phosphorylated Focal Adhesion Kinase In Vitro
por: Zhang, Gang, et al.
Publicado: (2017)

T cell-mediated elimination of cancer cells by blocking CEACAM6–CEACAM1 interaction
por: Pinkert, Jessica, et al.
Publicado: (2021)

The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
por: Ichikawa-Tomikawa, Naoki, et al.
Publicado: (2023)

Pathogenic interactions between Helicobacter pylori adhesion protein HopQ and human cell surface adhesion molecules CEACAMs in gastric epithelial cells
por: Xia, Ran, et al.
Publicado: (2019)

Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells
por: Skubitz, Keith M, et al.
Publicado: (2008)

CEACAMs: their role in physiology and pathophysiology
por: Kuespert, Katharina, et al.
Publicado: (2006)

Soluble CEACAM8 Interacts with CEACAM1 Inhibiting TLR2-Triggered Immune Responses
por: Singer, Bernhard B., et al.
Publicado: (2014)

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling
por: Eliceiri, Brian P., et al.
Publicado: (2002)

Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway
por: KONG, DEBO, et al.
Publicado: (2015)

Serum CEACAM1 Level Is Associated with Diagnosis and Prognosis in Patients with Osteosarcoma
por: Yu, Haiying, et al.
Publicado: (2016)

Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Effects of combining erlotinib and RNA-interfered downregulation of focal adhesion kinase expression on gastric cancer
por: Feng, Rui, et al.
Publicado: (2016)

Radiotherapy combined with anti-CEACAM1 immunotherapy to induce survival advantage in glioma
por: Li, Jinhu, et al.
Publicado: (2023)

CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associated With Refractory Neutropenia in Advanced Cirrhosis
por: Bihari, Chhagan, et al.
Publicado: (2022)

CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells
por: Muenzner, Petra, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_3ii5dunhjkjdp90pm49la9o9ad