Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis

Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes (DUBs) and find that the ubiquitin-specific pro...

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Detalles Bibliográficos
Autores principales: Jiang, Shuoyi, Wang, Xiaoge, He, Yuanming, Huang, Hongbiao, Cao, Biyin, Zhang, Zubin, Liu, Jinbao, Wang, Qi, Huang, Zhenqian, Mao, Xinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105359/
https://www.ncbi.nlm.nih.gov/pubmed/33963175
http://dx.doi.org/10.1038/s41419-021-03732-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105359/
https://www.ncbi.nlm.nih.gov/pubmed/33963175
http://dx.doi.org/10.1038/s41419-021-03732-6

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