Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461

CX-5461 is a G-quadruplex (G4) ligand currently in trials with initial indications of clinical activity in cancers with defects in homologous recombination repair. To identify more genetic defects that could sensitize tumors to CX-5461, we tested synthetic lethality for 480 DNA repair and genome mai...

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Detalles Bibliográficos
Autores principales: Masud, Tehmina, Soong, Charles, Xu, Hong, Biele, Justina, Bjornson, Saelin, McKinney, Steven, Aparicio, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105411/
https://www.ncbi.nlm.nih.gov/pubmed/33963218
http://dx.doi.org/10.1038/s41598-021-88988-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105411/
https://www.ncbi.nlm.nih.gov/pubmed/33963218
http://dx.doi.org/10.1038/s41598-021-88988-w

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