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CaMKII inhibition reduces arrhythmogenic Ca(2+) events in subendocardial cryoinjured rat living myocardial slices

Spontaneous Ca(2+) release (SCR) can cause triggered activity and initiate arrhythmias. Intrinsic transmural heterogeneities in Ca(2+) handling and their propensity to disease remodeling may differentially modulate SCR throughout the left ventricular (LV) wall and cause transmural differences in arr...

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Detalles Bibliográficos
Autores principales: Dries, Eef, Bardi, Ifigeneia, Nunez-Toldra, Raquel, Meijlink, Bram, Terracciano, Cesare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105719/
https://www.ncbi.nlm.nih.gov/pubmed/33956073
http://dx.doi.org/10.1085/jgp.202012737