Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer

BACKGROUND: Despite recent advances in diagnostic and therapeutic approaches for gastric cancer (GC), the survival of patients with advanced GC remains very low. Islet-1 (ISL1) is a LIM-homeodomain transcription factor, which is upregulated and promotes cell proliferation in GC. The exact mechanism...

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Detalles Bibliográficos
Autores principales: Shi, Qiong, Ni, Xiaomei, Lei, Ming, Xia, Quansong, Dong, Yan, Zhang, Qiao, Wang, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106192/
https://www.ncbi.nlm.nih.gov/pubmed/33962568
http://dx.doi.org/10.1186/s10020-021-00302-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106192/
https://www.ncbi.nlm.nih.gov/pubmed/33962568
http://dx.doi.org/10.1186/s10020-021-00302-6

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