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An intracellular nanobody targeting T4SS effector inhibits Ehrlichia infection
Infection with obligatory intracellular bacteria is difficult to treat, as intracellular targets and delivery methods of therapeutics are not well known. Ehrlichia translocated factor-1 (Etf-1), a type IV secretion system (T4SS) effector, is a primary virulence factor for an obligatory intracellular...
Autores principales: | Zhang, Wenqing, Lin, Mingqun, Yan, Qi, Budachetri, Khemraj, Hou, Libo, Sahni, Ashweta, Liu, Hongyan, Han, Nien-Ching, Lakritz, Jeffrey, Pei, Dehua, Rikihisa, Yasuko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106314/ https://www.ncbi.nlm.nih.gov/pubmed/33903242 http://dx.doi.org/10.1073/pnas.2024102118 |
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