Programming adaptive laboratory evolution of 4-hydroxyisoleucine production driven by a lysine biosensor in Corynebacterium glutamicum

4-Hydroxyisoleucine (4-HIL) is a promising drug for treating diabetes. In our previous study, 4-HIL was synthesized from self-produced L-isoleucine (Ile) in Corynebacterium glutamicum by expressing an Ile dioxygenase gene. Although the 4-HIL production of recombinant strain SZ06 increased significan...

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Detalles Bibliográficos
Autores principales: Yu, Xinping, Shi, Feng, Liu, Haiyan, Tan, Shuyu, Li, Yongfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106565/
https://www.ncbi.nlm.nih.gov/pubmed/33963930
http://dx.doi.org/10.1186/s13568-021-01227-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106565/
https://www.ncbi.nlm.nih.gov/pubmed/33963930
http://dx.doi.org/10.1186/s13568-021-01227-3

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