Cargando…

DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1

DNAJB9, a member of the heat shock protein 40 family, acts as a multifunctional player involved in the maintenance of their client proteins and cellular homeostasis. However, the mechanistic action of DNAJB9 in human malignancies is yet to be fully understood. In this study, we found that ectopic re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hye-Youn, Kim, Young-Mi, Hong, Suntaek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106677/ https://www.ncbi.nlm.nih.gov/pubmed/33966034 http://dx.doi.org/10.1038/s41419-021-03757-x

Ejemplares similares

Multi-Faceted Roles of DNAJB Protein in Cancer Metastasis and Clinical Implications
por: Kim, Hye-Youn, et al.
Publicado: (2022)

E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism
por: Shao, Jun, et al.
Publicado: (2022)

Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a
por: Kim, Hye-Youn, et al.
Publicado: (2019)

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation
por: Wu, Linhui, et al.
Publicado: (2022)

ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1
por: Song, Wei, et al.
Publicado: (2017)

FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
por: Qiao, Xinran, et al.
Publicado: (2023)

The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells
por: Deshayes, Natasja, et al.
Publicado: (2019)

TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway
por: Lin, Zhaoxian, et al.
Publicado: (2023)

FBXO45 is a potential therapeutic target for cancer therapy
por: Lin, Min, et al.
Publicado: (2020)

Pellino 3 promotes the colitis‐associated colorectal cancer through suppression of IRF4‐mediated negative regulation of TLR4 signalling
por: Kim, Young‐Mi, et al.
Publicado: (2023)

DNAJB4 promotes triple-negative breast cancer cell apoptosis via activation of the Hippo signaling pathway
por: Fang, Fang, et al.
Publicado: (2023)

DNAJB9 Is Not Transcriptionally Upregulated in the Glomerulus in Fibrillary Glomerulonephritis
por: Avasare, Rupali S., et al.
Publicado: (2019)

Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response
por: Andeen, Nicole K., et al.
Publicado: (2022)

DNAJB9-Positive Tubulointerstitial-Predominant Fibrillary Nephritis
por: Bourhis, Amelie, et al.
Publicado: (2023)

Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically activating ZEB2
por: Zhang, Guoxin, et al.
Publicado: (2019)

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1
por: Luo, Hong, et al.
Publicado: (2021)

FBXO22 degrades nuclear PTEN to promote tumorigenesis
por: Ge, Meng-Kai, et al.
Publicado: (2020)

DNAJB9 Is a Specific Immunohistochemical Marker for Fibrillary Glomerulonephritis
por: Nasr, Samih H., et al.
Publicado: (2017)

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
por: Qie, Shuo, et al.
Publicado: (2017)

Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation
por: Qu, Xingzhou, et al.
Publicado: (2021)

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
por: Jeon, Hyein, et al.
Publicado: (2016)

Fbxo45‐mediated NP‐STEP(46) degradation via K6‐linked ubiquitination sustains ERK activity in lung cancer
por: Wang, Qian, et al.
Publicado: (2022)

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection
por: Tsai, MuChun, et al.
Publicado: (2022)

FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis
por: Guo, Feng, et al.
Publicado: (2019)

FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis
por: Guo, Feng, et al.
Publicado: (2022)

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis
por: Ming, He, et al.
Publicado: (2018)

TRIM58 Interacts with ZEB1 to Suppress NSCLC Tumor Malignancy by Promoting ZEB1 Protein Degradation via UPP
por: Shang, Rongxin, et al.
Publicado: (2023)

FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression
por: Zhao, Yi, et al.
Publicado: (2021)

Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail
por: Tian, Yuan, et al.
Publicado: (2021)

DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation
por: Lee, Hyeon Ju, et al.
Publicado: (2020)

Fbxo22 inhibits metastasis in triple-negative breast cancer through ubiquitin modification of KDM5A and regulation of H3K4me3 demethylation
por: Li, Siqiaozhi, et al.
Publicado: (2022)

miR-1205/DNAJB1 reverses docetaxel chemoresistance in human triple negative breast carcinoma cells via regulation of mutp53/TAp63 signaling: miR-1205/DNAJB1 reverses docetaxel chemoresistance in TNBC
por: Yin, Yongxiang, et al.
Publicado: (2021)

Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells
por: Maturi, Varun, et al.
Publicado: (2018)

MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1
por: Deng, Yi, et al.
Publicado: (2017)

FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis
por: Johmura, Yoshikazu, et al.
Publicado: (2020)

DNAJB6b is Downregulated in Synucleinopathies
por: Folke, Jonas, et al.
Publicado: (2021)

On the micelle formation of DNAJB6b
por: Carlsson, Andreas, et al.
Publicado: (2023)

GPR110 promotes progression and metastasis of triple-negative breast cancer
por: Nam, Hye-Jung, et al.
Publicado: (2022)

YTHDF3 facilitates triple-negative breast cancer progression and metastasis by stabilizing ZEB1 mRNA in an m(6)A-dependent manner
por: Lin, Yuxiang, et al.
Publicado: (2022)

FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA
por: Kasuga, Yusuke, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fpqujiaetv2ljc0a7cf9f89rqf