WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis

FTO removes the N6-methyladenosine (m(6)A) modification from genes and plays a critical role in cancer development. However, the mechanisms underlying the regulation of FTO and its subsequent impact on the regulation of the epitranscriptome remain to be further elucidated. Here, we demonstrate that...

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Detalles Bibliográficos
Autores principales: Yang, Xueying, Shao, Fei, Guo, Dong, Wang, Wei, Wang, Juhong, Zhu, Rongxuan, Gao, Yibo, He, Jie, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106678/
https://www.ncbi.nlm.nih.gov/pubmed/33966037
http://dx.doi.org/10.1038/s41419-021-03739-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106678/
https://www.ncbi.nlm.nih.gov/pubmed/33966037
http://dx.doi.org/10.1038/s41419-021-03739-z

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