Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons

Carbonyl stress, a specific form of oxidative stress, is reported to be involved in the pathophysiology of schizophrenia; however, little is known regarding the underlying mechanism. Here, we found that disruption of GLO1, the gene encoding a major catabolic enzyme scavenging the carbonyl group, inc...

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Detalles Bibliográficos
Autores principales: Hara, Tomonori, Toyoshima, Manabu, Hisano, Yasuko, Balan, Shabeesh, Iwayama, Yoshimi, Aono, Harumi, Futamura, Yushi, Osada, Hiroyuki, Owada, Yuji, Yoshikawa, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106684/
https://www.ncbi.nlm.nih.gov/pubmed/33966051
http://dx.doi.org/10.1038/s41398-021-01392-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106684/
https://www.ncbi.nlm.nih.gov/pubmed/33966051
http://dx.doi.org/10.1038/s41398-021-01392-w

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