Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy

Synapses are particularly vulnerable in many neurodegenerative diseases and often the first to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, we describe an automated screening paradigm in zebr...

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Detalles Bibliográficos
Autores principales: Opris¸oreanu, Ana-Maria, Smith, Hannah L., Krix, Sophia, Chaytow, Helena, Carragher, Neil O., Gillingwater, Thomas H., Becker, Catherina G., Becker, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106959/
https://www.ncbi.nlm.nih.gov/pubmed/33973627
http://dx.doi.org/10.1242/dmm.047761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106959/
https://www.ncbi.nlm.nih.gov/pubmed/33973627
http://dx.doi.org/10.1242/dmm.047761

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