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Pyridostigmine improves cardiac function and rhythmicity through RyR2 stabilization and inhibition of STIM1‐mediated calcium entry in heart failure

Heart failure (HF) is characterized by asymmetrical autonomic balance. Treatments to restore parasympathetic activity in human heart failure trials have shown beneficial effects. However, mechanisms of parasympathetic‐mediated improvement in cardiac function remain unclear. The present study examine...

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Detalles Bibliográficos
Autores principales: Baine, Stephen, Bonilla, Ingrid, Belevych, Andriy, Stepanov, Andrei, Dorn, Lisa E., Terentyeva, Radmila, Terentyev, Dmitry, Accornero, Federica, Carnes, Cynthia A., Gyorke, Sandor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107086/
https://www.ncbi.nlm.nih.gov/pubmed/33755308
http://dx.doi.org/10.1111/jcmm.16356