Breaching the Delivery Barrier: Chemical and Physical Airway Epithelium Disruption Strategies for Enhancing Lentiviral-Mediated Gene Therapy

The lungs have evolved complex physical, biological and immunological defences to prevent foreign material from entering the airway epithelial cells. These mechanisms can also affect both viral and non-viral gene transfer agents, and significantly diminish the effectiveness of airway gene-addition t...

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Detalles Bibliográficos
Autores principales: McCarron, Alexandra, Farrow, Nigel, Cmielewski, Patricia, Knight, Emma, Donnelley, Martin, Parsons, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107471/
https://www.ncbi.nlm.nih.gov/pubmed/33981244
http://dx.doi.org/10.3389/fphar.2021.669635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107471/
https://www.ncbi.nlm.nih.gov/pubmed/33981244
http://dx.doi.org/10.3389/fphar.2021.669635

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