Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abno...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yanan, Wang, Canwei, Li, Jifa, Zhu, Jiandong, Zhao, Chengguang, Xu, Huanhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107720/
https://www.ncbi.nlm.nih.gov/pubmed/33981224
http://dx.doi.org/10.3389/fphar.2021.633453
_version_ 1783689998706409472
author Liu, Yanan
Wang, Canwei
Li, Jifa
Zhu, Jiandong
Zhao, Chengguang
Xu, Huanhai
author_facet Liu, Yanan
Wang, Canwei
Li, Jifa
Zhu, Jiandong
Zhao, Chengguang
Xu, Huanhai
author_sort Liu, Yanan
collection PubMed
description Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.
format Online
Article
Text
id pubmed-8107720
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81077202021-05-11 Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer Liu, Yanan Wang, Canwei Li, Jifa Zhu, Jiandong Zhao, Chengguang Xu, Huanhai Front Pharmacol Pharmacology Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4. Frontiers Media S.A. 2021-04-26 /pmc/articles/PMC8107720/ /pubmed/33981224 http://dx.doi.org/10.3389/fphar.2021.633453 Text en Copyright © 2021 Liu, Wang, Li, Zhu, Zhao and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Yanan
Wang, Canwei
Li, Jifa
Zhu, Jiandong
Zhao, Chengguang
Xu, Huanhai
Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
title Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
title_full Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
title_fullStr Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
title_full_unstemmed Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
title_short Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
title_sort novel regulatory factors and small-molecule inhibitors of fgfr4 in cancer
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107720/
https://www.ncbi.nlm.nih.gov/pubmed/33981224
http://dx.doi.org/10.3389/fphar.2021.633453
work_keys_str_mv AT liuyanan novelregulatoryfactorsandsmallmoleculeinhibitorsoffgfr4incancer
AT wangcanwei novelregulatoryfactorsandsmallmoleculeinhibitorsoffgfr4incancer
AT lijifa novelregulatoryfactorsandsmallmoleculeinhibitorsoffgfr4incancer
AT zhujiandong novelregulatoryfactorsandsmallmoleculeinhibitorsoffgfr4incancer
AT zhaochengguang novelregulatoryfactorsandsmallmoleculeinhibitorsoffgfr4incancer
AT xuhuanhai novelregulatoryfactorsandsmallmoleculeinhibitorsoffgfr4incancer

Ejemplares similares