Cargando…

The regulation of immune checkpoints by the hypoxic tumor microenvironment

The tumor microenvironment (TME) influences the occurrence and progression of tumors, and hypoxia is an important characteristic of the TME. The expression of programmed death 1 (PD1)/programmed death-ligand 1 (PDL1), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), and other immune checkpoints...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Min, Li, Yongfu, Lu, Yuting, Wang, Miao, Li, Yingrui, Wang, Chaoying, Li, Qin, Zhao, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2021
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109006/ https://www.ncbi.nlm.nih.gov/pubmed/34012727 http://dx.doi.org/10.7717/peerj.11306

Ejemplares similares

The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment
por: Qin, Hanjiao, et al.
Publicado: (2018)

Exosomal microRNA remodels the tumor microenvironment
por: Jiang, Xiaoli, et al.
Publicado: (2017)

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages
por: Freedman, Tanya S, et al.
Publicado: (2015)

Glucosylceramide synthase regulates hepatocyte repair after concanavalin A-induced immune-mediated liver injury
por: Gan, Jian, et al.
Publicado: (2021)

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage
por: Li, Jiao, et al.
Publicado: (2022)

Micromanaging checkpoint proteins
por: Ciliberto, Andrea, et al.
Publicado: (2017)

Construction of a ceRNA network of regulated ferroptosis in doxorubicin-induced myocardial injury
por: Ye, Hongwei, et al.
Publicado: (2023)

Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment
por: Gao, Jian-Li, et al.
Publicado: (2015)

Neuromedin U and neurotensin may promote the development of the tumour microenvironment in neuroblastoma
por: Yang, Daheng, et al.
Publicado: (2021)

Multi-Omics Analysis of the Anti-tumor Synergistic Mechanism and Potential Application of Immune Checkpoint Blockade Combined With Lenvatinib
por: Lu, Yuting, et al.
Publicado: (2021)

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments
por: Wei, Xiaoxu, et al.
Publicado: (2021)

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling
por: Ji, Zhejian, et al.
Publicado: (2017)

Targeting breast cancer with a combination of DNT and LAG3 checkpoint blockage and its mechanism
por: Wang, Miao, et al.
Publicado: (2022)

Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signaling
por: Li, Wanzhen, et al.
Publicado: (2022)

Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression
por: Wei, Yuhan, et al.
Publicado: (2022)

CG4968 positively regulates the immune deficiency pathway by targeting Imd protein in Drosophila
por: Li, Qingyang, et al.
Publicado: (2023)

RNA binding proteins involved in regulation of protein synthesis to initiate biogenesis of secondary tumor in hepatocellular carcinoma in mice
por: Li, Genliang, et al.
Publicado: (2020)

Exosome-orchestrated hypoxic tumor microenvironment
por: Meng, Wanrong, et al.
Publicado: (2019)

LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis
por: Wang, Xu, et al.
Publicado: (2022)

Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1
por: Wang, Zijia, et al.
Publicado: (2023)

Differential expression of checkpoint markers in the normoxic and hypoxic microenvironment of glioblastomas
por: Petterson, Stine Asferg, et al.
Publicado: (2022)

Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints
por: Xu, Yaolin, et al.
Publicado: (2021)

Design of new acid-activated cell-penetrating peptides for tumor drug delivery
por: Yao, Jia, et al.
Publicado: (2017)

EMT-related gene expression is positively correlated with immunity and may be derived from stromal cells in osteosarcoma
por: Peng, Yin-xiao, et al.
Publicado: (2020)

Down-regulated NEDD4L facilitates tumor progression through activating Notch signaling in lung adenocarcinoma
por: Lin, Liping, et al.
Publicado: (2022)

Microorganism-regulated autophagy in gastrointestinal cancer
por: Xu, Jun-Yu, et al.
Publicado: (2023)

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
por: Overlack, Katharina, et al.
Publicado: (2015)

Heat treatment-induced autophagy promotes breast cancer cell invasion and metastasis via TGF-β2-mediated epithelial-mesenchymal transitions
por: Li, Zhennan, et al.
Publicado: (2023)

Prognostic value and immune cell infiltration of hypoxic phenotype‐related gene signatures in glioblastoma microenvironment
por: Xiao, Kai, et al.
Publicado: (2020)

Hyperthermia Targeting the Tumor Microenvironment Facilitates Immune Checkpoint Inhibitors
por: Li, Zihui, et al.
Publicado: (2020)

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy
por: Zemek, Rachael M., et al.
Publicado: (2020)

Proteolytic maturation of α(2)δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels
por: Kadurin, Ivan, et al.
Publicado: (2016)

Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice
por: Wen, Zongzhuang, et al.
Publicado: (2022)

The nexus of dynamic T cell states and immune checkpoint blockade therapy in the periphery and tumor microenvironment
por: Luo, Hong, et al.
Publicado: (2023)

The Impact of NOTCH Pathway Alteration on Tumor Microenvironment and Clinical Survival of Immune Checkpoint Inhibitors in NSCLC
por: Li, Xiaohua, et al.
Publicado: (2021)

N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats
por: Pan, Yitong, et al.
Publicado: (2021)

Aspirin inhibits tumor progression and enhances cisplatin sensitivity in epithelial ovarian cancer
por: Guo, Jianfeng, et al.
Publicado: (2021)

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer
por: Zhou, Qian, et al.
Publicado: (2021)

Transcriptional regulation of Bcl-2 gene by the PR/SET domain family member PRDM10
por: Chen, Na, et al.
Publicado: (2019)

Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors
por: Eckert, Franziska, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0gmc27sm3i7c9qaif3k37iotgl