TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response

RIG-I-like receptors (RLRs) are involved in the discrimination of self versus non-self via the recognition of double-stranded RNA (dsRNA). Emerging evidence suggests that immunostimulatory dsRNAs are ubiquitously expressed but are disrupted or sequestered by cellular RNA binding proteins (RBPs). TDP...

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Detalles Bibliográficos
Autores principales: Dunker, William, Ye, Xiang, Zhao, Yang, Liu, Lanxi, Richardson, Antiana, Karijolich, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109599/
https://www.ncbi.nlm.nih.gov/pubmed/33852834
http://dx.doi.org/10.1016/j.celrep.2021.108976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109599/
https://www.ncbi.nlm.nih.gov/pubmed/33852834
http://dx.doi.org/10.1016/j.celrep.2021.108976

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