Phe-Gly motifs drive fibrillization of TDP-43’s prion-like domain condensates

Transactive response DNA-binding Protein of 43 kDa (TDP-43) assembles various aggregate forms, including biomolecular condensates or functional and pathological amyloids, with roles in disparate scenarios (e.g., muscle regeneration versus neurodegeneration). The link between condensates and fibrils...

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Detalles Bibliográficos
Autores principales: Pantoja-Uceda, David, Stuani, Cristiana, Laurents, Douglas V., McDermott, Ann E., Buratti, Emanuele, Mompeán, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109789/
https://www.ncbi.nlm.nih.gov/pubmed/33909608
http://dx.doi.org/10.1371/journal.pbio.3001198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109789/
https://www.ncbi.nlm.nih.gov/pubmed/33909608
http://dx.doi.org/10.1371/journal.pbio.3001198

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