There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions

Drug dosing decisions in clinical medicine and in introducing a drug to market for the past 60 years are based on the pharmacokinetic/clinical pharmacology concept of clearance. We used chemical reaction engineering models to demonstrate the limitations of presently employed clearance measurements b...

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Detalles Bibliográficos
Autores principales: Benet, Leslie Z., Sodhi, Jasleen K., Makrygiorgos, George, Mesbah, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110503/
https://www.ncbi.nlm.nih.gov/pubmed/33973074
http://dx.doi.org/10.1208/s12248-021-00591-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110503/
https://www.ncbi.nlm.nih.gov/pubmed/33973074
http://dx.doi.org/10.1208/s12248-021-00591-z

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