Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth

We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells. We first present their in vitro and membrane activity, before we address their mechanism of action in living cells and in vivo activity. We sho...

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Detalles Bibliográficos
Autores principales: Hébert, Audrey, Parisotto, Maxime, Rowell, Marie-Camille, Doré, Alexandra, Fernandez Ruiz, Ana, Lefrançois, Guillaume, Kalegari, Paloma, Ferbeyre, Gerardo, Schmitzer, Andreea R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110578/
https://www.ncbi.nlm.nih.gov/pubmed/33972583
http://dx.doi.org/10.1038/s41598-021-87993-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110578/
https://www.ncbi.nlm.nih.gov/pubmed/33972583
http://dx.doi.org/10.1038/s41598-021-87993-3

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