Cargando…
Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth
We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells. We first present their in vitro and membrane activity, before we address their mechanism of action in living cells and in vivo activity. We sho...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110578/ https://www.ncbi.nlm.nih.gov/pubmed/33972583 http://dx.doi.org/10.1038/s41598-021-87993-3 |