Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles

BACKGROUND: Immune checkpoint blockers (ICBs) activate CD8(+) T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear. METHODS: Retrospective evaluation of irAEs on survival was perform...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Weiyu, Olsson-Brown, Anna, Watson, Robert A., Cheung, Vincent T. F., Morgan, Robert D., Nassiri, Isar, Cooper, Rosalin, Taylor, Chelsea A., Akbani, Umair, Brain, Oliver, Matin, Rubeta N., Coupe, Nicholas, Middleton, Mark R., Coles, Mark, Sacco, Joseph J., Payne, Miranda J., Fairfax, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110747/
https://www.ncbi.nlm.nih.gov/pubmed/33723392
http://dx.doi.org/10.1038/s41416-021-01310-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110747/
https://www.ncbi.nlm.nih.gov/pubmed/33723392
http://dx.doi.org/10.1038/s41416-021-01310-3

Ejemplares similares