Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most common and lethal ovarian cancer histotype. Chromosome instability (CIN, an increased rate of chromosome gains and losses) is believed to play a fundamental role in the development and evolution of HGSOC. Importantly, overexpression of...

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Detalles Bibliográficos
Autores principales: Lepage, Chloe Camille, Palmer, Michaela Cora Lynn, Farrell, Ally Catherina, Neudorf, Nicole Marie, Lichtensztejn, Zelda, Nachtigal, Mark William, McManus, Kirk James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110794/
https://www.ncbi.nlm.nih.gov/pubmed/33731859
http://dx.doi.org/10.1038/s41416-021-01317-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110794/
https://www.ncbi.nlm.nih.gov/pubmed/33731859
http://dx.doi.org/10.1038/s41416-021-01317-w

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