Cargando…

Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most common and lethal ovarian cancer histotype. Chromosome instability (CIN, an increased rate of chromosome gains and losses) is believed to play a fundamental role in the development and evolution of HGSOC. Importantly, overexpression of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lepage, Chloe Camille, Palmer, Michaela Cora Lynn, Farrell, Ally Catherina, Neudorf, Nicole Marie, Lichtensztejn, Zelda, Nachtigal, Mark William, McManus, Kirk James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110794/ https://www.ncbi.nlm.nih.gov/pubmed/33731859 http://dx.doi.org/10.1038/s41416-021-01317-w

Ejemplares similares

Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover
por: Thompson, Laura L., et al.
Publicado: (2020)

Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells
por: Neudorf, Nicole M., et al.
Publicado: (2022)

The F-box protein, FBXO7, is required to maintain chromosome stability in humans
por: Palmer, Michaela C L, et al.
Publicado: (2021)

Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability
por: Thompson, Laura L., et al.
Publicado: (2022)

Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells
por: Sajesh, Babu V., et al.
Publicado: (2013)

Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis
por: Mathur, Radhika, et al.
Publicado: (2015)

Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
por: Sajesh, Babu V, et al.
Publicado: (2013)

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples
por: Penner-Goeke, Signe, et al.
Publicado: (2017)

A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members
por: Campos Gudiño, Rubi, et al.
Publicado: (2021)

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
por: Baergen, Allison K., et al.
Publicado: (2019)

Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes
por: Leylek, Tarik R., et al.
Publicado: (2020)

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
por: Rowland, Rhianna J., et al.
Publicado: (2023)

Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis
por: Jeusset, Lucile M., et al.
Publicado: (2021)

The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition
por: McAndrew, Erin N., et al.
Publicado: (2016)

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases
por: Zhou, Weihua, et al.
Publicado: (2013)

Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity
por: Lepage, Chloe C., et al.
Publicado: (2019)

3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"
por: Knecht, Hans, et al.
Publicado: (2010)

Referral, Genetic Counselling, and BRCA Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019
por: Winchar, Kelcey, et al.
Publicado: (2022)

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
por: Emberley, Ethan D., et al.
Publicado: (2012)

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation
por: Salamina, Marco, et al.
Publicado: (2021)

Cul4B promotes the progression of ovarian cancer by upregulating the expression of CDK2 and CyclinD1
por: Duan, Peng-jing, et al.
Publicado: (2020)

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
por: Yu, Qing, et al.
Publicado: (2020)

The Proto-Oncogene Int6 Is Essential for Neddylation of Cul1 and Cul3 in Drosophila
por: Rencus-Lazar, Sigal, et al.
Publicado: (2008)

Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)(FBXW11-NSs) E3 Ligase
por: Mudhasani, Rajini, et al.
Publicado: (2016)

The Conserved Function of Skp1 in Meiosis
por: McLoud, Josh D., et al.
Publicado: (2012)

Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain
por: Dabool, Lital, et al.
Publicado: (2020)

Cyclin D-CDK4 kinase destabilizes PD-L1 via Cul3(SPOP) to control cancer immune surveillance
por: Zhang, Jinfang, et al.
Publicado: (2017)

Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis
por: Wu, Shuilian, et al.
Publicado: (2021)

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability
por: Lepage, Chloe C., et al.
Publicado: (2020)

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability
por: Thompson, Laura L., et al.
Publicado: (2021)

Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
por: Martinez, Victor D., et al.
Publicado: (2014)

Modification of Cul1 regulates its association with proteasomal subunits
por: Bloom, Joanna, et al.
Publicado: (2006)

LZTR1: A promising adaptor of the CUL3 family
por: Zhang, Hui, et al.
Publicado: (2021)

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer
por: Thompson, Laura L., et al.
Publicado: (2017)

Polymorphisms of CUL5 Are Associated with CD4(+) T Cell Loss in HIV-1 Infected Individuals
por: An, Ping, et al.
Publicado: (2007)

CUL1 promotes trophoblast cell invasion at the maternal–fetal interface
por: Zhang, Q, et al.
Publicado: (2013)

SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression
por: Samara, Tjam Diana, et al.
Publicado: (2019)

Inhibitory effect of CUL1 on atherosclerosis through the p53 pathway
por: Zhang, Xi, et al.
Publicado: (2022)

Structural, Expression and Interaction Analysis of Rice SKP1-Like Genes
por: Kahloul, Senda, et al.
Publicado: (2013)

Skp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer
por: Yu, Xinfang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_odupa854s57bi9ag25upj26r9k