Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin

Shiga toxin (Stx) is a major virulence factor of enterohemorrhagic Escherichia coli, which causes fatal systemic complications. Here, we identified a tetravalent peptide that inhibited Stx by targeting its receptor-binding, B-subunit pentamer through a multivalent interaction. A monomeric peptide wi...

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Detalles Bibliográficos
Autores principales: Watanabe-Takahashi, Miho, Tamada, Masakazu, Senda, Miki, Hibino, Masahiro, Shimizu, Eiko, Okuta, Akiko, Miyazawa, Atsuo, Senda, Toshiya, Nishikawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111002/
https://www.ncbi.nlm.nih.gov/pubmed/33972673
http://dx.doi.org/10.1038/s42003-021-02068-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111002/
https://www.ncbi.nlm.nih.gov/pubmed/33972673
http://dx.doi.org/10.1038/s42003-021-02068-3

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