A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers

PT150, a novel competitive glucocorticoid receptor (GR) antagonist, has proven safe in animal models, healthy volunteers, and people with depression. Our study is the first to investigate PT150’s safety with alcohol use. The primary objective of this study was to evaluate pharmacodynamic interaction...

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Detalles Bibliográficos
Autores principales: Morice, Claire, Baker, Dewleen G., Patel, Marguerite M., Nolen, Tracy L., Nowak, Kayla, Hirsch, Shawn, Kosten, Thomas R., Verrico, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111026/
https://www.ncbi.nlm.nih.gov/pubmed/33972573
http://dx.doi.org/10.1038/s41598-021-88609-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111026/
https://www.ncbi.nlm.nih.gov/pubmed/33972573
http://dx.doi.org/10.1038/s41598-021-88609-6

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