Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

Alpha-synuclein (α-syn) mislocalization and accumulation in intracellular inclusions is the major pathological hallmark of degenerative synucleinopathies, including Parkinson’s disease, Parkinson’s disease with dementia and dementia with Lewy bodies. Typical symptoms are behavioural abnormalities in...

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Detalles Bibliográficos
Autores principales: Bridi, Jessika C, Bereczki, Erika, Smith, Saffron K, Poças, Gonçalo M, Kottler, Benjamin, Domingos, Pedro M, Elliott, Christopher J, Aarsland, Dag, Hirth, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111063/
https://www.ncbi.nlm.nih.gov/pubmed/33997781
http://dx.doi.org/10.1093/braincomms/fcab049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111063/
https://www.ncbi.nlm.nih.gov/pubmed/33997781
http://dx.doi.org/10.1093/braincomms/fcab049

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