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Prion potentiation after life-long dormancy in mice devoid of PrP
Prions are neurotropic pathogens composed of misfolded assemblies of the host-encoded prion protein PrP(C) which replicate by recruitment and conversion of further PrP(C) by an autocatalytic seeding polymerization process. While it has long been shown that mouse-adapted prions cannot replicate and a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111064/ https://www.ncbi.nlm.nih.gov/pubmed/33997785 http://dx.doi.org/10.1093/braincomms/fcab092 |