npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

Niemann-Pick type C (NPC) disease is an autosomal recessive lysosomal storage disease that is caused by a mutation of the NPC1 or NPC2 gene, in which un-esterified cholesterol and sphingolipids accumulate mainly in the liver, spleen, and brain. Abnormal lysosomal storage leads to cell damage, neurol...

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Detalles Bibliográficos
Autores principales: Wiweger, Malgorzata, Majewski, Lukasz, Adamek-Urbanska, Dobrochna, Wasilewska, Iga, Kuznicki, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111220/
https://www.ncbi.nlm.nih.gov/pubmed/33986646
http://dx.doi.org/10.3389/fncel.2021.647860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111220/
https://www.ncbi.nlm.nih.gov/pubmed/33986646
http://dx.doi.org/10.3389/fncel.2021.647860

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