Cargando…

Synthesis of 10-O-aryl-substituted berberine derivatives by Chan–Evans–Lam coupling and investigation of their DNA-binding properties

Eleven novel 10-O-aryl-substituted berberrubine and berberine derivatives were synthesized by the Cu(2+)-catalyzed Chan–Evans–Lam coupling of berberrubine with arylboronic acids and subsequent 9-O-methylation. The reaction is likely introduced by the Cu(2+)-induced demethylation of berberrubine and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wickhorst, Peter Jonas, Blachnik, Mathilda, Lagumdzija, Denisa, Ihmels, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111429/
https://www.ncbi.nlm.nih.gov/pubmed/34025807
http://dx.doi.org/10.3762/bjoc.17.81