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Synthesis of 10-O-aryl-substituted berberine derivatives by Chan–Evans–Lam coupling and investigation of their DNA-binding properties
Eleven novel 10-O-aryl-substituted berberrubine and berberine derivatives were synthesized by the Cu(2+)-catalyzed Chan–Evans–Lam coupling of berberrubine with arylboronic acids and subsequent 9-O-methylation. The reaction is likely introduced by the Cu(2+)-induced demethylation of berberrubine and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111429/ https://www.ncbi.nlm.nih.gov/pubmed/34025807 http://dx.doi.org/10.3762/bjoc.17.81 |