CD1a selectively captures endogenous cellular lipids that broadly block T cell response

We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM). The natural 42:2 SM but not the more common...

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Detalles Bibliográficos
Autores principales: Cotton, Rachel N., Wegrecki, Marcin, Cheng, Tan-Yun, Chen, Yi-Ling, Veerapen, Natacha, Le Nours, Jérôme, Orgill, Dennis P., Pomahac, Bohdan, Talbot, Simon G., Willis, Richard, Altman, John D., de Jong, Annemieke, Van Rhijn, Ildiko, Clark, Rachael A., Besra, Gurdyal S., Ogg, Graham, Rossjohn, Jamie, Moody, D. Branch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111460/
https://www.ncbi.nlm.nih.gov/pubmed/33961028
http://dx.doi.org/10.1084/jem.20202699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111460/
https://www.ncbi.nlm.nih.gov/pubmed/33961028
http://dx.doi.org/10.1084/jem.20202699

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