DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells

DNMT3A encodes an enzyme that carries out de novo DNA methylation, which is essential for the acquisition of cellular identity and specialized functions during cellular differentiation. DNMT3A is the most frequently mutated gene in age-related clonal hematopoiesis. As such, mature immune cells harbo...

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Detalles Bibliográficos
Autores principales: Lim, Jung-Yeon, Duttke, Sascha H., Baker, Turner S., Lee, Jihye, Gambino, Kristyne J., Venturini, Nicholas J., Ho, Jessica Sook Yuin, Zheng, Simin, Fstkchyan, Yesai S., Pillai, Vinodh, Fajgenbaum, David C., Marazzi, Ivan, Benner, Christopher, Byun, Minji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111463/
https://www.ncbi.nlm.nih.gov/pubmed/33970190
http://dx.doi.org/10.1084/jem.20202733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111463/
https://www.ncbi.nlm.nih.gov/pubmed/33970190
http://dx.doi.org/10.1084/jem.20202733

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