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Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes

BACKGROUND: The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration structure. However, the key components of this pathw...

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Detalles Bibliográficos
Autores principales: Wang, Luyao, Wen, Pei, van de Leemput, Joyce, Zhao, Zhanzheng, Han, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111712/
https://www.ncbi.nlm.nih.gov/pubmed/33975644
http://dx.doi.org/10.1186/s13578-021-00595-4