Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Radiotherapy is an effective option for the treatment of TNBC; however, acquired radioresistance is a major challenge to the modality. In this study, we show that the integrated stress response (ISR) is the most activ...

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Detalles Bibliográficos
Autores principales: Bai, Xupeng, Ni, Jie, Beretov, Julia, Wasinger, Valerie C., Wang, Shanping, Zhu, Ying, Graham, Peter, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111851/
https://www.ncbi.nlm.nih.gov/pubmed/33946018
http://dx.doi.org/10.1016/j.redox.2021.101993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111851/
https://www.ncbi.nlm.nih.gov/pubmed/33946018
http://dx.doi.org/10.1016/j.redox.2021.101993

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