Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the brain, Aβ exists as a pool of distinct C-terminal variants with le...

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Detalles Bibliográficos
Autores principales: Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M., Lau, Heather H. C., Stuart, Erica, Kovacs, Gabor G., Nilsson, K. Peter R., Fraser, Paul E., Schmitt-Ulms, Gerold, Watts, Joel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112054/
https://www.ncbi.nlm.nih.gov/pubmed/33971978
http://dx.doi.org/10.1186/s40478-021-01187-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112054/
https://www.ncbi.nlm.nih.gov/pubmed/33971978
http://dx.doi.org/10.1186/s40478-021-01187-6

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