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Therapeutic Effects of Gleditsia sinensis Thorn Extract Fermented by Lactobacillus casei 3260 in a Type II Collagen-Induced Rheumatoid Arthritis Mouse Model
This study aimed to assess the anti-inflammatory effect of Lactobacillus casei 3260 (LC) alone and LC-fermented Gleditsia sinensis thorn (GST) extract in mouse model of type II collagen induced rheumatoid arthritis (RA). In our previous work, we confirmed the anti-inflammatory effects of LC and GST...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Food Science of Animal Resources
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112306/ https://www.ncbi.nlm.nih.gov/pubmed/34017957 http://dx.doi.org/10.5851/kosfa.2021.e13 |
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author | Eor, Ju Young Park, Nahyun Son, Yoon Ji Kim, Sae Hun |
author_facet | Eor, Ju Young Park, Nahyun Son, Yoon Ji Kim, Sae Hun |
author_sort | Eor, Ju Young |
collection | PubMed |
description | This study aimed to assess the anti-inflammatory effect of Lactobacillus casei 3260 (LC) alone and LC-fermented Gleditsia sinensis thorn (GST) extract in mouse model of type II collagen induced rheumatoid arthritis (RA). In our previous work, we confirmed the anti-inflammatory effects of LC and GST against LPS-induced inflammation in vitro. In this study, LC and GST were fermented and their effects were assessed in an animal model of RA. Both LC and fermented GST (fGST) treatment reduced mice serum nitrite and total cholesterol and triggered myeloperoxidase (MPO) activity. In addition, both LC and fGST reduced inflammation-related serum biomarkers such as tumor necrosis factor-α, interleukin (IL)-6, IL-17, and IL-1β. As per the morphological analysis, both LC and fGST protected hind paw joints against RA, and its related mRNA markers improved. Finally, arthritis scores were measured as an indicator of RA of the whole experimental period; the scores suggested that both LC and fGST protect against collagen-induced RA-related inflammation in a mouse model. |
format | Online Article Text |
id | pubmed-8112306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Food Science of Animal Resources |
record_format | MEDLINE/PubMed |
spelling | pubmed-81123062021-05-19 Therapeutic Effects of Gleditsia sinensis Thorn Extract Fermented by Lactobacillus casei 3260 in a Type II Collagen-Induced Rheumatoid Arthritis Mouse Model Eor, Ju Young Park, Nahyun Son, Yoon Ji Kim, Sae Hun Food Sci Anim Resour Article This study aimed to assess the anti-inflammatory effect of Lactobacillus casei 3260 (LC) alone and LC-fermented Gleditsia sinensis thorn (GST) extract in mouse model of type II collagen induced rheumatoid arthritis (RA). In our previous work, we confirmed the anti-inflammatory effects of LC and GST against LPS-induced inflammation in vitro. In this study, LC and GST were fermented and their effects were assessed in an animal model of RA. Both LC and fermented GST (fGST) treatment reduced mice serum nitrite and total cholesterol and triggered myeloperoxidase (MPO) activity. In addition, both LC and fGST reduced inflammation-related serum biomarkers such as tumor necrosis factor-α, interleukin (IL)-6, IL-17, and IL-1β. As per the morphological analysis, both LC and fGST protected hind paw joints against RA, and its related mRNA markers improved. Finally, arthritis scores were measured as an indicator of RA of the whole experimental period; the scores suggested that both LC and fGST protect against collagen-induced RA-related inflammation in a mouse model. Korean Society for Food Science of Animal Resources 2021-05 2021-05-01 /pmc/articles/PMC8112306/ /pubmed/34017957 http://dx.doi.org/10.5851/kosfa.2021.e13 Text en © Korean Society for Food Science of Animal Resources https://creativecommons.org/licenses/by-nc/3.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Eor, Ju Young Park, Nahyun Son, Yoon Ji Kim, Sae Hun Therapeutic Effects of Gleditsia sinensis Thorn Extract Fermented by Lactobacillus casei 3260 in a Type II Collagen-Induced Rheumatoid Arthritis Mouse Model |
title | Therapeutic Effects of Gleditsia sinensis Thorn
Extract Fermented by Lactobacillus casei 3260 in a Type II
Collagen-Induced Rheumatoid Arthritis Mouse Model |
title_full | Therapeutic Effects of Gleditsia sinensis Thorn
Extract Fermented by Lactobacillus casei 3260 in a Type II
Collagen-Induced Rheumatoid Arthritis Mouse Model |
title_fullStr | Therapeutic Effects of Gleditsia sinensis Thorn
Extract Fermented by Lactobacillus casei 3260 in a Type II
Collagen-Induced Rheumatoid Arthritis Mouse Model |
title_full_unstemmed | Therapeutic Effects of Gleditsia sinensis Thorn
Extract Fermented by Lactobacillus casei 3260 in a Type II
Collagen-Induced Rheumatoid Arthritis Mouse Model |
title_short | Therapeutic Effects of Gleditsia sinensis Thorn
Extract Fermented by Lactobacillus casei 3260 in a Type II
Collagen-Induced Rheumatoid Arthritis Mouse Model |
title_sort | therapeutic effects of gleditsia sinensis thorn
extract fermented by lactobacillus casei 3260 in a type ii
collagen-induced rheumatoid arthritis mouse model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112306/ https://www.ncbi.nlm.nih.gov/pubmed/34017957 http://dx.doi.org/10.5851/kosfa.2021.e13 |
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