Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters

In this work, we have developed and tested a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters to gather data about its toxicology and pharmacokinetics. Niclosamide, a poorly water-soluble drug, is an interesting drug candidate bec...

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Detalles Bibliográficos
Autores principales: Jara, Miguel O., Warnken, Zachary N., Sahakijpijarn, Sawittree, Moon, Chaeho, Maier, Esther Y., Christensen, Dale J., Koleng, John J., Peters, Jay I., Hackman Maier, Sarah D., Williams III, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112893/
https://www.ncbi.nlm.nih.gov/pubmed/33989748
http://dx.doi.org/10.1016/j.ijpharm.2021.120701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112893/
https://www.ncbi.nlm.nih.gov/pubmed/33989748
http://dx.doi.org/10.1016/j.ijpharm.2021.120701

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