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Redox regulation of the insulin signalling pathway

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which mediates fundamental cellular responses. Oxidants, in particular H(2)O(2), have been recognised as insulin-mimetics. Tr...

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Detalles Bibliográficos
Autores principales: Lennicke, Claudia, Cochemé, Helena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113030/
https://www.ncbi.nlm.nih.gov/pubmed/33893069
http://dx.doi.org/10.1016/j.redox.2021.101964