Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination

BACKGROUND: A combination of the antipsychotic olanzapine and opioid receptor antagonist samidorphan (OLZ/SAM) is in development for the treatment of patients with schizophrenia or bipolar I disorder. The effect of severe renal impairment on the pharmacokinetics of olanzapine and samidorphan after a...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Lei, von Moltke, Lisa, Rowland Yeo, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113183/
https://www.ncbi.nlm.nih.gov/pubmed/33313995
http://dx.doi.org/10.1007/s40262-020-00969-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113183/
https://www.ncbi.nlm.nih.gov/pubmed/33313995
http://dx.doi.org/10.1007/s40262-020-00969-w

Ejemplares similares