Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

The present study predicts in vivo human and rat red blood cell (RBC) acetylcholinesterase (AChE) inhibition upon diazinon (DZN) exposure using physiological based kinetic (PBK) modelling-facilitated reverse dosimetry. Due to the fact that both DZN and its oxon metabolite diazoxon (DZO) can inhibit...

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Detalles Bibliográficos
Autores principales: Zhao, Shensheng, Wesseling, Sebastiaan, Spenkelink, Bert, Rietjens, Ivonne M. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113213/
https://www.ncbi.nlm.nih.gov/pubmed/33715020
http://dx.doi.org/10.1007/s00204-021-03015-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113213/
https://www.ncbi.nlm.nih.gov/pubmed/33715020
http://dx.doi.org/10.1007/s00204-021-03015-1

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