Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the development of improved drugs in the future....

Descripción completa

Detalles Bibliográficos
Autores principales: Kudo, Kei, Nishimura, Takehiro, Kozone, Ikuko, Hashimoto, Junko, Kagaya, Noritaka, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113240/
https://www.ncbi.nlm.nih.gov/pubmed/33976244
http://dx.doi.org/10.1038/s41598-021-88583-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113240/
https://www.ncbi.nlm.nih.gov/pubmed/33976244
http://dx.doi.org/10.1038/s41598-021-88583-z

Ejemplares similares