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Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase
Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the development of improved drugs in the future....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113240/ https://www.ncbi.nlm.nih.gov/pubmed/33976244 http://dx.doi.org/10.1038/s41598-021-88583-z |