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EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function
HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate proteins. By deacetylating histones and non-histone proteins, HDAC1 has a profound effect on the regulation of gene transcription and many p...
Autores principales: | Bahl, Sonali, Ling, Hongbo, Acharige, Nuwan P. N., Santos-Barriopedro, Irene, Pflum, Mary Kay H., Seto, Edward |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113371/ https://www.ncbi.nlm.nih.gov/pubmed/33976119 http://dx.doi.org/10.1038/s41419-021-03697-6 |
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